The Treatment of Kala-Azar by Diamidino Stilbene : Analysis of 101 Cases
نویسندگان
چکیده
Introduction.?About eighteen months ago, we (Napier and Sen, 1940) published a preliminary paper on the treatment of kala-azar by 4 : 4'-diamidino stilbene. At the time our paper was sent to press, there were in the literature? that had arrived in this country?only two detailed reports on cases treated by this drug (Adams and Yorke, 1939; and Adler and Rachmilewitz, 1939). Since then a small spate of reports has appeared. Kirk and Sati (1940) treated 8 cases of Sudanese kala-azar with remarkable success. Adams and Yorke (1940) treated a second case of Indian kala-azar. A further report by Kirk and Sati (1940a) referred to the treatment of 28 cases by this drug?this number presumably included the original 8 cases previously reported?and another 16 cases treated by allied compounds?the ' immediate-
منابع مشابه
Observations on the Neuropathic Sequel of Diamidino-Stilbene Therapy in Kala-Azar
Diamidino-stilbene is by far the most potent of the aromatic diamidines tested so far in the treatment of kala-azar. The immediate cure rate in Indian kala-azar is about 98 per cent, and the proportion of cases relapsing after a single course of treatment is very low. The use of this drug has however certain drawbacks. The intravenous injections are usually accompanied by certain unpleasant rea...
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Hydroxystilbamidine or 4 : 4'-diamidino 2-hydroxy-stilbene di-jS-hydroxy-ethane sulphonate was first used by the writer for the treatment of kala-azar in 1948 and 1949 and a paper based on the results of treatment of the first six cases published (Sen Gupta, 1949). All the six cases treated had recovered and had remained free from all symptoms of kala-azar for 5, 5, 5, 4}2-, 34, and 3 months re...
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Early last, year, Napier and Sen Gupta (1943) published a preliminary report on the treatment of kala-azar with 4 : 4' diamidinodiphenoxy-pentane. Thirty-two cases of kalaazar, 11 of which were 'resistant' cases, were treated, and 10 out of these 11 cases and 19 out of the remaining 1 ordinary' cases made a prompt recovery. Two patients died of associated complications during the course of trea...
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